Tag Archives: nitric oxide

More Truth about Sun Exposure

By Marc Sorenson, EdD… Sun exposure benefits…

A very important paper regarding the necessity for sun exposure has recently been published by the journal Medical Hypothesis.[1] It is entitled Regular sun exposure benefits health, and it discusses the pros and cons of sun exposure. One of the salient statements in the paper is that intermittent sun exposure may increase the risk of skin cancer, whereas regular exposure to sunlight might benefit health. For those of us who have for years studied the beneficial effects of sun exposure, the use of the word “might” is the only drawback to the statement. There is no doubt that for the majority of the population, regular sun exposure absolutely protects and enhances health.

Among the diseases mentioned as being reduced or prevented by regular sun exposure are the following:

  1. Cancers: Colon, breast, prostate and non-Hodgkin lymphoma
  2. Multiple sclerosis
  3. Hypertension
  4. Diabetes

As the authors mention, most of these positive effects of sun exposure were previously ascribed to Vitamin D, but they point out that immune system function is enhanced by sun exposure beyond the effects of vitamin D, and list other non-vitamin D benefits of the sun, including:

  1. Production of nitric oxide
  2. Production of melatonin
  3. Production of serotonin
  4. Regulation of the circadian clock

I have discussed most of these items on the Sunlight Institute web site, but it was good to see new research that, in particular, separated the health benefits of sun exposure from vitamin D production. The idea that has become popularized during the past decade, that all benefits of sun exposure come from increased vitamin D production, is simply not true and can lead to the supplementation of vitamin D as a “cure” for diseases that may not be influenced by that hormone.

Of course, vitamin D is an exceptionally important photoproduct, and the only natural way to attain it is by exposure to the sun or to other sources of UVB light (such as a sunlamp or a tanning bed). The beauty of using these sources, rather than a vitamin-D capsule, is that all of the benefits of nitric oxide, melatonin, serotonin and circadian entrainment are included in the package.

Safely enjoy the sun, and you then will also safely enjoy better health. Remember not to burn, and to gradually develop a good tan.

[1]  van der Rhee H, de Vries, E, Coebergh, J. Regular sun exposure benefits health. Medical Hypotheses 97 (2016) 34–37

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Sun Exposure reduces Obesity; Vitamin D does not.

By Marc Sorenson, EdD. Sunlight Institute…

Sun exposure reduces the risk of obesity, and that relationship has been credited to vitamin D. However, one study, conducted on mice, shows that vitamin D may have nothing to do with reducing or preventing obesity.[1] The animals were placed on a high-fat diet to cause obesity. Then they were subjected to long-term exposure to ultraviolet radiation (UVR), (which is the same sunlight spectrum that leads to the production of vitamin D and other photoproducts). The UVR significantly suppressed weight gain and other measures of the metabolic syndrome (MetS), including glucose intolerance, insulin resistance, fasting insulin levels, fatty liver disease and serum cholesterol levels.

Interestingly, when the animals were supplemented with vitamin D, no such benefits occurred, meaning that UVR created the positive protections independently. However when nitric oxide was applied to the skin of the animals, the positive effects on weight loss and metabolic syndrome were again observed. Nitric oxide, of course, is another photoproduct of sun exposure, which has many positive health effects.

Other research showed that early-morning sun exposure was correlated to lower body-mass index (BMI) which is a measure of body fatness.[2] The authors of that research suggested that the mechanisms involved in weight control by early light exposure could be the following: (1) resetting the circadian rhythm (internal clock), (2) the greater quantity of blue light in morning sun and (3) effects on melatonin production. Whatever the mechanisms, we now know that early-morning sun is important to weight control. It may also be important to other health issues. But before we begin to think that sun exposure is the cure-all for obesity, realize that poor nutritional habits and lack of exercise are much more important. Nevertheless, sun exposure can furnish one more arrow in the quiver of protection from obesity.

Get your sun exposure and stay slim! Be careful not to burn.

[1] Geldenhuys S, Hart PH, Endersby R, Jacoby P, Feelisch M, Weller RB, Matthews V, Gorman S. Ultraviolet radiation suppresses obesity and symptoms of metabolic syndrome independently of vitamin D in mice fed a high-fat diet. Diabetes. 2014 Nov;63(11):3759-69.

[2] Reid KJ, Santostasi G, Baron KG, Wilson J, Kang J, Zee PC. Timing and intensity of light correlate with body weight in adults. PLoS One 2014;2;9(4)

 

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New Research paper states that Sun exposure is less dangerous than vitamin D supplements.

In a new scientific paper, Dr. MS Razzaque shows that there may be some downsides to vitamin D supplementation, including “cardiovascular events and beyond.” He also states that “since hypovitaminosis D status usually reflects reduced sunlight exposure, the obvious primary replacement should be safe sunlight exposure, and not exogenous supplements.”[1]

The paper specifically mentions that avoiding sunlight exposure may influence the initiation and progression of different types of tumors [cancer], high blood pressure, type 1 diabetes and multiple sclerosis. It also points out that there may be some deleterious consequences of vitamin D supplementation, although in my opinion, the dosage would need to by quite high.

As I have indicated in many of my posts on the Sunlight Institute site, sun exposure is the most natural way to obtain vitamin D, and it has no toxicity, since it is self-regulated.

What wasn’t mentioned was the production of health-promoting substances when sun touches the skin, e.g. endorphins and nitric oxide. And of course, the sun helps the brain to produce serotonin and BDNF, which are critical for proper brain function.

So soak up your sunlight but don’t burn.

[1] Razzaque MS. Sunlight exposure: Do health benefits outweigh harm? J Steroid Biochem Mol Biol. 2016 Sep 16. [Epub ahead of print].

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High blood pressure (Hypertension). Is it caused by low vitamin D levels, sun deprivation or both?

By Marc Sorenson, EdD. Sunlight Institute… promoting safe sun exposure…

It has long been known that vitamin D deficiency is associated with hypertension. But could that association really be a measurement of inadequate sun exposure? A most interesting investigation was carried out this month (July 2016) in which the researchers evaluated over 1100 subjects from an ongoing study called “the Reasons for Racial and Geographic Differences in Stroke.” They measured vitamin D levels and also assessed sun exposure levels, and found that both high vitamin D levels and high sun exposure levels were associated with higher blood pressure.[1]

What makes this research different is that when the data was adjusted for other factors, high sun exposure was even more impressive as a protective factor against high blood pressure. However, adjusting for vitamin D levels had no effect on the association of sun exposure to lower blood pressure; for each increase in sun exposure, there was a corresponding decrease in blood pressure, but the same was not true for increases or decreases in vitamin D levels.

The researchers made this statement: “We conclude that although 25(OH)D concentration is inversely associated with SBP, it did not explain the association of greater sunlight exposure with lower BP.”

To me, this research indicates that sun exposure directly effects lower blood pressure levels, independently of vitamin D. This is not surprising, since clinical trials of vitamin D supplementation have found only small effects on blood pressure.[2]

I hypothesize that nitric oxide (NO), is the mechanism by which sun exerts its impressive effects. NO is a potent vasodilator, and when it is released into the arteries by UVA stimulation, causes increased blood flow and lowers blood pressure.[3] [4] Dr. Oplander and his colleagues wrote the first paper on the UVA, NO and blood pressure in 2009,[5] and Dr. Richard Weller has been a leader in doing research and granting interviews on NO since that time. He has made two interesting statements: (1) “We suspect that the benefits to heart health of sun will outweigh the risk of skin cancer. The work we have done provides a mechanism that might account for this, and also explains why dietary vitamin D supplements alone will not be able to compensate for lack of sun.”[6] (2) “Although the benefits of sun are often attributed to vitamin D, a gas called nitric oxide is also important. Made when the sun hits our skin, nitric oxide lowers blood pressure when it enters the bloodstream. Although the reduction is small, it could ‘make a big difference.”[7]

A study from China also demonstrates that exposure to sun correlates to a lowered risk of hypertension.[8] In a randomly selected population of Chinese residents from Macau (where the rate of hypertension is very high), the following risk factors for hypertension were assessed: lack of sun exposure, low intake of fish, smoking, obesity and lack of exercise. An average of more than one-half hour of sun exposure per day compared to none predicted a 40% reduced risk for hypertension.

Vitamin D has many marvelous health effects, but sun exposure per se has many more, because not only does the sun stimulate the production on vitamin D, it also produces other vital photoproducts such as NO, endorphins and serotonin. When we avoid the sun and simply take a vitamin D pill, we are short-changing ourselves for the total package of benefits derived from the sun. And in the case of high blood pressure, we may be receiving almost no benefit from vitamin D. Think about it, and enjoy the sun safely.

[1] Rostand SG, McClure LA, Kent ST, Judd SE, Gutiérrez OM. Associations of blood pressure, sunlight, and vitamin D in community-dwelling adults. J Hypertens. 2016 Jul 1. [Epub ahead of print]

[2] Beveridge LA, Struthers AD, Khan F, Jorde R, Scragg R, Macdonald HM, Alvarez JA, Boxer RS. Et. al. Effect of Vitamin D Supplementation on Blood Pressure: A Systematic Review and Meta-analysis Incorporating Individual Patient Data. AMA Intern Med. 2015 May;175(5):745-54.

[3] Liu D, Fernandez BO, Hamilton A, Lang NN, Gallagher JM, Newby DE, Feelisch M, Weller RB. UVA irradiation of human skin vasodilates arterial vasculature and lowers blood pressure independently of nitric oxide synthase. J Invest Dermatol. 2014 Jul;134(7):1839-46.

[4] D Liu, BO Fernandez, NN Lang, JM Gallagher, DE Newby, M Feelisch and RB Weller. UVA lowers blood pressure and vasodilates the systemic arterial vasculature by mobilization of cutaneous nitric oxide stores. Photobiology Abstract # 1247 May 2013.

[5] Opländer C, Volkmar CM, Paunel-Görgülü A, van Faassen EE, Heiss C, Kelm M, Halmer D, Mürtz M, Pallua N, Suschek CV.. Whole body UVA irradiation lowers systemic blood pressure by release of nitric oxide from intracutaneous photolabile nitric oxide derivates. Circ Res. 2009;105:1031–40.

[6] Quoted on Mercola.com  http://articles.mercola.com/sites/articles/archive/2013/07/15/sun-exposure.aspx accessed July 2, 2015.

[7] Weller, R. Shunning the sun may be killing you in more ways than you think. New Scientist July 2, 2015.

[8] Ke L, Ho J, Feng J, Mpofu E, Dibley MJ, Feng X, Van F, Leong S, Lau W, Lueng P, Kowk C, Li Y, Mason RS, Brock KE. Modifiable risk factors including sun exposure and fish consumption are associated with risk of hypertension in a large representative population from Macau. J Steroid Biochem Mol Biol 2013 Nov 1 [Epub ahead of print].

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Men, protect your Prostate!. Research demonstrates a positive influence of Sun Exposure on Prostate Cancer.

By Marc Sorenson, EdD. Sunlight Institute.

Regular sun exposure is one of the best ways to reduce the risk of many cancers. Although the relationship of sun exposure (and vitamin D) to the risk of prostate cancer is controversial, a study from Australia, published in 2011, showed that the less sun exposure, the greater the risk of the cancer.[1] The researchers investigated the relationship between prostate cancer incidence and solar radiation in non-urban Australia and found an inverse association. There are many other studies that indicate a protective effect of sun exposure. One of the earliest was conducted by Dr. Esther John and her colleagues: they compared the lifetime sun exposure of 450 white men with advanced prostate cancer to that of 455 white men who did not have cancer.[2] The men were divided into quintiles according to the amount of exposure they had received.  Subjects in the highest fifth of sun exposure had only 51% of the risk of prostate cancer as did those in the lowest quintile.

Another study on cancer that corroborated these observations was entitled: Is prevention of cancer by sun Exposure more than just the effect of vitamin D? A systematic review of epidemiological studies.[3] In their review, the authors noted that regular sun exposure correlated to a reduced risk of colorectal cancer, prostate cancer, breast cancer and non-Hodgkin’s lymphoma (NHL). However, vitamin D levels correlated to a reduced risk of colorectal, and to a lesser extent, breast cancer, but were not correlated to a significant risk reduction in prostate cancer and non-Hodgkin’s lymphoma. The authors concluded with this statement: “Particularly in prostate cancer and NHL, other sun-potentiated and vitamin D-independent pathways, such as modulation of the immune system and the circadian rhythm, and the degradation of folic acid, might play a role in reduced cancer risk as well.” These researchers did well to remind us, that as important as vitamin D is to the human body, other effects of sun exposure may be more important in some diseases. The authors could have also mentioned the effect of sun on vasodilation, mediated by the production of nitric oxide (produced by the skin after sun exposure). They could also have discussed the influence of sun on production of serotonin and endorphins, all of which may have contributed to their observations.

Other research used childhood sunburn as a measure of UVR exposure and determined that men who had sunburned as children had only about one-fifth the risk of contracting prostate cancer as those who had not sunburned.[4]  A note of caution! We are not recommending that anyone sunburn in order to prevent prostate or other types of cancer. Sunburn was used in this research to predict higher vitamin D levels, but it is not necessary to achieve those levels, since non-burning sun exposure achieves the same results. This research also demonstrated that men with lowest level of UVR exposure had more than triple the risk of prostate cancer and that onset of the disease was delayed more than four years in those who had the greatest exposure compared to those who had the least exposure.  A follow-up to this study, reported that men in the lowest quartile of sunbathing were linked to a 5.33-fold greater risk of prostate cancer than those in the highest quartile. Still other research has indicated that “higher levels of cumulative exposure, adult sunbathing, childhood sunburn and regular holidays in hot climates were each independently and significantly associated with a reduced risk of this [prostate] cancer.[5]

So men, protect your prostate by regular, non-burning sun exposure. Don’t let the Powers of Darkness frighten you away from the sun.

[1] Loke TW, Seyfi D, Khadra M. Prostate cancer incidence in Australia correlates inversely with solar radiation. BJU Int. 2012 Apr;109 Suppl 3:75.

[2] John EM, Schwartz GG, Koo J, Van Den Berg D, Ingles SA.  Sun exposure, vitamin D receptor gene polymorphisms, and risk of advanced prostate cancer.  Cancer Res 2005;65(12):5470-79.

[3] van der Rhee H, Coebergh JW, de Vries E. Is prevention of cancer by sun exposure more than just the effect of vitamin D? A systematic review of epidemiological studies. Eur J Cancer. 2013 Apr;49(6):1422-36.

[4] Moon SJ, Fryer AA, Strange RC.  Ultraviolet radiation: effects on risks of prostate cancer and other internal cancers.  Mutat Res 2005;571(1-2):207-19.

[5] Bodiwala D, Luscombe CJ, Liu S, Saxby M, French M, Jones PW, Fryer AA, Strange RC..  Prostate cancer risk and exposure to ultraviolet radiation: further support for the protective effect of sun.  Cancer Lett 2003;192:145-49.

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More on Sun Exposure and Depression

Does sun exposure help fight depression? Of course!

By Marc Sorenson, EdD. Sunlight Exposure

Although this blog has discussed sun exposure and its affects on depression, there is some information that I may have neglected to mention. It has been shown that depressed psychiatric patients who resided in sunny rooms stayed in the hospital 2.6 fewer days than those who had “dull” rooms.[1] The sunny rooms had windows, so it is likely that endorphins and serotonin, created by the sun entering the windows, were the natural “uppers” by which the patients felt better. Nitric oxide, produced by UVA light exposure, could also have played a part.

Another of those dull rooms is the one that houses the TV. An interesting study from the University of Pittsburgh found that the more TV teenagers watched, the more likely they were to be depressed as adults.[2] The study author theorized that because there is so much depressing news and programming on TV, the more exposure, the more the internalizing or the depressing programming. For each hour of TV watched, the rate of depression increased significantly.

The researchers may be correct, or it could be that hours of sedentary life in front of the TV, watching commercials for junk food, leads to obesity and poor health as the teenager ages.  We have another theory that may supplant, or at least add to those theories. It is possible that years of unnatural indoor habits create deficiency of the aforementioned vitamin D, nitric oxide, endorphins and serotonin, which may have long-term effects. Combined with the deleterious influences of excessive TV watching, that could be a recipe for depression and health disasters. Sun exposure and vitamin D are absolutely necessary for human health and happiness.  An indoor lifestyle is unnatural and damaging to the human body and psyche.

Safely embrace the sun and obtain its “feel-good” effects.

 

[1] Beauchemin KM, Hays P. Sunny hospital rooms expedite recovery from severe and refractory depressions. J Affect Disord. 1996 Sep 9;40(1-2):49-51.

[2]Primack, B.  Association between media use in adolescence and depression in young adulthood: a longitudinal study.  Arch Gen Psychiatry. 2009 Feb;66(2):181-8

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Sun Exposure during Mothers’ Pregnancy may prevent Asthma in Children.

By Marc Sorenson,, EdD. Sunlight Institute…

The medical properties are terrific! A new study from the University of Kansas demonstrates that children born to women who receive more sun exposure during the second trimester of pregnancy, have a considerably lowered risk of asthma later in life.[1] The researchers did not look at sunny geographical areas vs. areas of little sun to make their assessments, but rather looked at different amounts of sunlight occurring in the same areas in different years. They found that in areas that had experienced high quantities of sun in a given year, the risk of asthmatic children being born in that year was reduced, that is, if their mothers experienced that sun exposure during the second trimester of pregnancy.

The researchers theorized that higher levels of vitamin D during sunny times accounted for the protective effects of sunlight. That may be true, but the protection may have occurred from sun exposure per se, independent of vitamin D. One of the most recent studies on factors that contribute to asthma showed that living in a room without windows was associated with an increased the risk of asthma of 930%,  and living in an area without adequate sun was associated with an increased the risk of 220%.[2] Considering that windows filter out the UVB light that stimulates the production of vitamin D, having windows could not have reduced asthma by vitamin D production—it had to be some other factor—something that entered the room through that window glass–protected the people with windows from the remarkable increase in asthma they would have otherwise had. We know that UVA light, which does pass through windows, stimulates the production of nitric oxide, which is a potent vasodilator. Could it also be a bronchodilator? This explanation, of course, is theory.

Whatever the reason, the study on sunlight and pregnancy is just one of many that have indicated a protective effect of sun exposure against asthma. Safely embrace the sun, and tell pregnant mothers to do the same. It could enhance the quality of life for their children later on, and reduce the cost of health care for all of us.

[1] http://www.biospace.com/News/asthma-free-it-might-be-because-of-moms-sunny/413945

[2] Kamran A, Hanif S, Murtaza G. Risk factors of childhood asthma in children attending Lyari General Hospital. J Pak Med Assoc 2015 Jun;65(6):647-50.

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Nitric Oxide can have positive Effects on Cancer. Another Reason to seek the Sun.

By Marc Sorenson, EdD. Sunlight Institute…

Dr. Richard Weller has promoted sun exposure as a method of increasing nitric oxide (NO) in the vascular system, thereby lowering the risk of heart disease.[1] NO is a potent vasodilator that lowers blood pressure, which according to the World Health Organization, is the leading cause of premature death and disease worldwide.1 But NO may have other beneficial effects.

There is also research showing that NO, which is also an oxidant, has the ability to retard or reverse tumor growth, making it a potential anti-cancer therapy.[2] The problem with this of course, is that if it is used as an anticancer treatment, the oxidation has the potential to harm other systems of the body; After all, that is why we use antioxidants. However, the body beautifully controls the natural use of oxidants to specifically target tumors and leave healthy tissue untouched. As one group of researchers states: “…there is considerable controversy and confusion in understanding its role [NO) in cancer biology. It is said to have both tumoricidal as well as tumor promoting effects which depend on its timing, location, and concentration.[3]

The best way to use NO, in my opinion, is to let nature take its course and use sun exposure to produce NO. Then, the body’s natural physical process will use oxidation to destroy tumors and simultaneously reduce the risk of cancer.

Safely enjoy the sun.

[1] Richard B. Weller.  Sunlight Has Cardiovascular Benefits Independently of Vitamin D. Blood Purif 2016;41:130–134.

[2] Jordi Muntané and Manuel De la Mata. Nitric oxide and cancer. Nitric Oxide and Cancer. Journal List. World J Hepatolv.2(9); 2010 Sep 27.

[3] Sheetal Korde Choudhari, Minal Chaudhary, Sachin Bagde, Amol R Gadbail, and Vaishali Joshi. Nitric oxide and cancer: a review. World J Surg Oncol. 2013; 11: 118.

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Sun Exposure, Chronic Fatigue and Vitamin D

By Marc Sorenson, EdD, Sunlight Institute…

A recent post by an online paper called The Korea Bizwire talks of research by Dr. Emad Al Duzahiri, in which he concludes that those who are suffering from chronic fatigue may really be suffering from sun deficiency.[1] The article mentions that vitamin D, preferably from sun exposure, is essential for reducing the risk of the disease.

There is at least one additional study indicating that optimization of vitamin D improves the severity of symptoms in those who suffer from fatigue.[2]

Remember that sun exposure is the best way to obtain your vitamin D, because it also comes along with serotonin, nitric oxide, endorphins and perhaps dopamine, and it profoundly improves the mood—just what the doctor ordered for chronic fatigue.

So when your get-up-and-go has gotten up and gone, don’t forget the sun!

[1] Emad Al Duzahiri. Quoted in The Korea Bizwire, January 19, 2016. http://koreabizwire.com/lack-of-exposure-to-sunlight-may-lead-to-chronic-fatigue/48480 (accessed January 20, 2016)

[2] Roy S, Sherman A, Monari-Sparks MJ, Schweiker O, Hunter K. Correction of Low Vitamin D Improves Fatigue: Effect of Correction of Low Vitamin D in Fatigue Study (EViDiF Study). N Am J Med Sci. 2014 Aug;6(8):396-402.

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Sun Exposure, Nitric Oxide and Vitamin D for improved Athletic Performance

By Marc Sorenson, EdD  Sunlight Institute…

A most interesting research paper demonstrates that nitrate supplements, combined with exposure to sunlight, increases performance of cyclists.[1] The researchers state that “dietary nitrate supplementation has been shown to increase nitric oxide (NO) metabolites, reduce blood pressure (BP) and enhance exercise performance.” And, as we have discussed in this blog, sun exposure reduces BP by increasing the production of NO. It was theorized that sun exposure might enhance the athletic performance induced by the dietary nitrate supplementation.

The theory proved to be correct; although sun exposure did not improve cycling times by itself, when combined with the nitrate supplementation, cycling times improved significantly.

It may surprise some people to realize that ultraviolet radiation (UVR) from sun beds or sun lamps has been used since before 1950 to enhance athletic performance.[2] As early as 1938, Russian researchers reported that a course of UVR significantly improved speed in the 100-meter dash among four students when compared with controls that did not have the radiation, although both groups were undergoing identical daily training.[3] The non-irradiated group improved by 1.7% but the irradiated group improved by 7.4%. Another study conducted over ten weeks showed that cardiovascular endurance improved remarkably among athletes in training who were irradiated vs. those who were not.[4] The irradiated athletes improved by 19.2% compared to 1.5% among the non-irradiated group.

There are numerous studies from Germany showing the efficacy of UVR on athletic performance, most of them from the early days before the idea of sun-lamp produced UVR fell into disrepute because of the attack on tanning beds. What a shame. This method of athletic assistance could produce an impressive improvement in sports performance for so many people, athletic or not. Strength improves, stamina improves, quickness improves and speed improves with UVR radiation, which of course is also part of sunlight. The mechanism for this improvement is likely a combination of vitamin D and nitric oxide.

Safely enjoy the sun!

 

 

 

[1] Muggeridge DJ, Sculthorpe N, Grace FM, Willis G, Thornhill L, Weller RB, James PE, Easton C. Acute whole body UVA irradiation combined with nitrate ingestion enhances time trial performance in trained cyclists. Nitric Oxide. 2015 Aug 1;48:3-9.

[2] Cannell JJ, Hollis BW, Sorenson MB, Taft TN, Anderson JJ. Athletic performance and vitamin D. Med Sci Sports Exerc. 2009 May;41(5):1102-10.

[3] Gorkin Z. Gorkin MJ, Teslenko NE. The effect of ultraviolet radiation upon training for the 100-meter sprint.

[4] Allen R, Cureton T. Effects of ultraviolet radiation on physical fitness. Arch Phys Med 1945;10:641-4.

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